Distinct Genomic Profiles in Hereditary Breast Tumors Identified by Array-Based Comparative Genomic Hybridization
نویسندگان
چکیده
منابع مشابه
Distinct genomic profiles in hereditary breast tumors identified by array-based comparative genomic hybridization.
Mutations in BRCA1 and BRCA2 account for a significant proportion of hereditary breast cancers. Earlier studies have shown that inherited and sporadic tumors progress along different somatic genetic pathways and that global gene expression profiles distinguish between these groups. To determine whether genomic profiles similarly discriminate among BRCA1, BRCA2, and sporadic tumors, we establish...
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Identification of prognostic and predictive genomic markers requires long-term clinical follow-up of patients. Extraction of high-quality DNA from archived formalin-fixed, paraffin-embedded material is essential for such studies. Of particular importance is a robust reproducible method of whole genome amplification for small tissue samples. This is especially true for high-resolution analytical...
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We read with interest the article by Baldwin et al. (1), which describes the use of an array of 32,433 bacterial artificial chromosome clones tiled across the genome (2, 3) to map genomic aberrations in 20 oral squamous cell carcinoma samples by array comparative genomic hybridization (array CGH). The authors conclude that improved detection sensitivity and resolution of tiling arrays is necess...
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BACKGROUND Oral cancer typically affects smokers older than 50 years of age. Recently, however, a marked increase in the number of patients 40 years old and younger, many with no history of tobacco smoking, has been noted. Studies in this age group have so far been restricted to genomic areas well recognized as abnormal in typical patients with oral cancer. The aim of this study was to assess g...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2005
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-05-0570